High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity …
MM Poulsen, PF Vestergaard, BF Clasen, Y Radko… - Diabetes, 2013 - Am Diabetes Assoc
Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and
premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk
factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but
data in human subjects are scarce. The objective of this study was to examine the metabolic
effects of high-dose resveratrol in obese human subjects. In a randomized, placebo-
controlled, double-blinded, and parallel-group design, 24 obese but otherwise healthy men …
premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk
factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but
data in human subjects are scarce. The objective of this study was to examine the metabolic
effects of high-dose resveratrol in obese human subjects. In a randomized, placebo-
controlled, double-blinded, and parallel-group design, 24 obese but otherwise healthy men …
[PDF][PDF] An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
MM Poulsen, PF Vestergaard, BF Clasen, Y Radko… - Diabetes, 2013 - findresearcher.sdu.dk
RESEARCH DESIGN AND METHODS Ethical approval. All participants were given oral and
written information before written informed consent was obtained. The protocol was
approved by the Regional Committee on Health Research Ethics and the Danish Data
Protection Agency, and the study was conducted in agreement with the Declaration of
Helsinki II. According to the International Committee of Medical Journal Editors, the protocol
was registered at clinicaltrials. gov (NCT01150955) before recruitment was initiated …
written information before written informed consent was obtained. The protocol was
approved by the Regional Committee on Health Research Ethics and the Danish Data
Protection Agency, and the study was conducted in agreement with the Declaration of
Helsinki II. According to the International Committee of Medical Journal Editors, the protocol
was registered at clinicaltrials. gov (NCT01150955) before recruitment was initiated …
以上显示的是最相近的搜索结果。 查看全部搜索结果